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SAMe and Methionine Depletion on the Body SAMe (S-adenosylmethionine) and methionine are essential components of the methylation pathway, a critical process involved in many essential bodily functions

This in silico framework provides a platform from which GSH depletion can be explored as a function of a compounds physicochemical properties

& Kohn, B

At 5 units (maintenance), each component is exactly half that

Each condition was conducted in triplicates, subject to a freeze/thaw cycle and incubated with the DNA intercalant SYBR Gold following manufacturer instructions (SYBR Gold Nucleic Acid Stain, Invitrogen)