Even if cysteine S -conjugate -lyase is responsible for the synthesis of the highly reactive and cytotoxic thiol version of cisplatin ( Figure 1 ), the activation of cisplatin into a nephrotoxin relies on the three previous steps of the classical mercapturic acid pathway involving GSTs (GSH conjugation), GT (production of CisPt-cys-glu) and dipeptidase (production of CisPt-cys
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The protective effect of auraptene against oxidative stress and pentylenetetrazol-induced chemical kindling in mice
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Many adults lack magnesium in their diets
10.1007/s13105-016-0523-3 [DOI] [PubMed] [Google Scholar] Kobayashi E