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GSH dysfunction not only impairs GPX4 activity but also mobilizes intracellular Fe 2 + , thereby accelerating lipid peroxidation and ferroptotic death 131,132

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Eun Young, K., Fengjiao, C., Hyun Kyung, K., Hadia, N., Sumin, K., Hayoon, K., Jihye, J., & Gwang-woong, G

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In addition, mitochondria are also the primary producers of intracellular reactive oxygen species (ROS), most of which originate from the mitochondrial respiratory chain [55]