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Thus, multienzyme-like reactions of NPs can simultaneously inhibit GPX4 and the FSP1-CoQ10H2 pathway in TNBC cells to promote ferroptosis, providing a promising avenue for the clinical treatment of drug-resistant tumors

However, this large number warrants important context: 35 of the 36 studies included in the systematic review were preclinical (conducted in laboratory or animal models), and only one clinical study met the review's inclusion criteria

Ucak UV, et al

Khavinson VK, Egorova VV, Timofeeva NM, Malinin VV, Gordova LA, Gromova LV

Appetite changes often occur early in treatment