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National Library of Medicine

Some patients may struggle to absorb enough B12 from diet or oral supplements, especially those with conditions like pernicious anemia, gastrointestinal disorders, or those who have undergone certain surgeries

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Anecdotal reports of users running 6+ months show continued effectiveness without significant issues

Folate deficiency caused by a lack of dietary folate is more common in people who have a generally unbalanced and unhealthy diet, people who regularly misuse alcohol, and people following a restrictive diet that does not involve eating good sources of folate

It is normally involved in the metabolism of every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid metabolism and amino acid metabolism