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However, most individuals with MTHFR variants still convert cyanocobalamin adequately

Nayana Shetty, MBBS, MD Health Risks Associated with High B12 In some cases, high vitamin B12 levels symptoms can include unusual symptoms like anxiety or a rapid heartbeat, which are more likely associated with the underlying condition, not the elevated B12 levels themselves

Understanding these helps set realistic expectations and optimize your protocol

Blood levels rise across the first several weekly doses and settle near steady state after about four weeks. That is why the four-week hold matters: the full effect of a dose change is not visible in the first few days

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