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High glucose can inhibit podocyte autophagy through AMPK pathway (Plat et al., 2020) and activate the mTOR signaling to inhibit podocyte autophagy

Health 39 , 170177 (2013)

In aging models, it restores youthful gene expression patterns, increasing protective factors and reducing genes associated with inflammation or degeneration

Inhibiting macrophage-capping protein suppresses UFM1-mediated pirin modification, which downregulates GPX4 transcription and promotes HMGB1 cytosolic translocation, ultimately triggering ferroptosis and rapid release of this damage-associated molecular pattern (91)

Several recent studies have shown that inflammation and oxidative stress may play a key role in supporting the pathogenesis and the severity of ASD