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Often irritation appears as a symptom of that damage, although this may occur at a sub-clinical level
Topical calcineurin inhibitors (TCI) and moderate to high potency corticosteroids (TCS), which both reduce the cellular immune response, are the first-line treatments for vitiligo
Comparable effectiveness to IV glutathione in studies
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Beyond the patient comfort it aims to provide, a monthly dosage form is intended to reduce the currently very high discontinuation rate for these treatments observed within the first year and thus address their main limitation, given that all expected benefits are long-term and disappear when treatment is discontinued
It is always adjunctive therapy, never monotherapy
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