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doi: 10.1039/C9RA03848E 143 XingF.HuQ.QinY.XuJ.ZhangB.YuX.et al

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7.4 Improvement of translational and clinical research We also emphasize the importance of well-designed animal studies and clinical investigations to validate the safety, efficacy, and mechanisms of gutliver axistargeted interventions, thereby facilitating their potential translation into clinical applications

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Pregnancy and lactation represent relative contraindications given absence of human safety data in these populations despite reassuring preclinical reproductive toxicology studies