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This increased glutathione pool may help contend with the increased flow of free radicals from dysfunctional mitochondria

Stachulski AV, Baillie TA, Park BK, Obach RS, Dalvie DK, Williams DP, et al

Latter involves the B microspecies of reduced glutathione, and the corresponding E microspecies of glutathione disulfide and can be expressed in relation with the MNA + /MNAH system by the following equation: Note that the involvement of B necessitates the involvement of E (see Fig

However, the loss of p21 Cip1 alone is insufficient to induce apoptosis and was actually shown to induce a senescence-escape instead (Brown et al., 1997)

Angew Chem Int Ed Engl