Fialaire et al., Thermal decomposition of reduced glutathione in solution for organ preservation (1992), J Pharm Biomed Anal., DOI 10.1016/0731-7085(92)80064-T Provides evidence for the thermal decomposition of glutathione when heated in solution
However, quantitative human bioavailability data are not publicly available, so the degree of intact peptide absorption in humans remains unconfirmed
However, glutathione is exceptionally fragile
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The chronic and distressing nature of tinnitus involves the deep engagement of non-auditory brain regions
Furthermore, the molecular weight of LOX (32 kDa) approaches the upper limits of collagen type I pore size, estimated to be between 5.7 kDa and 48 kDa, which may limit LOX ability to diffuse into the fibril (Toroian et al ., 2007)