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However, in genetically predisposed individuals, a subset of autoreactive T cells can evade these mechanisms, become activated, proliferate, and differentiate, initiating an autoimmune cascade (Fig

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In severe PEM, there is a marked decline in the hepatic synthesis of transport proteins including thyroxine-binding globulin (TBG), thyroxine-binding pre-albumin (TBPA), and albumin [32]

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