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While this approach was effective for marketing, it often oversimplified the complexity of skin biology

Biochem Pharmacol 2015;93:40917

Cell studies, animal studies, and small older cohorts

The concentrations of IL-17 and TNF-, two important proinflammatory cytokines, were prominently increased, whereas those of certain chemokines, such as RANTES, MIP-1, MIP-1, and MCP-1, were markedly decreased in MS-affected patients compared with those in healthy controls

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