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Kidney Int 1990;38:912-8

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In a singleton pregnancy the total increase of plasma volume accounts to 12001400 ml which is around 40 % above the volume of a non-pregnant woman, whereas in a multiple pregnancy this expansion is much bigger (Reference Pinheiro and Stika22)

1,2 Although the clinical diagnosis of PD relies on the appearance of motor manifestations, extensive neuropathological dissemination initiates decades earlier, posing a significant challenge for early diagnosis

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