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We further show that PG/VG aerosols increase the expression of inflammatory markers and MUC5AC

As nicotine levels drop, symptoms such as restlessness, low mood, and anxiety re-emerge, reinforcing the cycle of dependence. Beyond psychological explanations, nicotines interaction with the hypothalamicpituitaryadrenal (HPA) axis, which regulates the stress response, provides a biological basis for its effects on mood

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