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Second, the specific roles of obesity and aging in OA pathogenesis remain incompletely defined and may vary across different populations, contributing to inconsistencies in current findings
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Faride Ramos frames it in Empire's functional gut health course, the honest clinical position is to separate two things: increased intestinal permeability , which is a real and measurable physiological state, and leaky gut syndrome, the broader functional-medicine label that is not formally recognized as a standalone diagnosis
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