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This mineral, apart from being an important player in Se-anti-carcinogenesis by way of its intermediary Se-metabolites, or as an essential component of antioxidant enzymes that are active in the removal of reactive oxygen and nitrogen species, has been found to affect DNA methylation by interfering with DNMT activity ( Reference Davis and Uthus 58 )

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4 Discussion Melanoma is a malignant tumor with low survival rates that originates from melanocytes [212]