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2.2 Cryptococcus Cryptococcosis is a life-threatening invasive fungal infection primarily caused by Cryptococcus neoformans and Cryptococcus gattii , accounting for approximately 152,000 new cases and 110,000 deaths annually, predominantly among immunocompromised individuals such as HIV/AIDS patients and organ transplant recipients (Kwon-Chung et al., 2014)

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Liew Z, et al

However, its antioxidant properties may help reduce oxidative damage to melanocytes, potentially slowing the process

Mutations in Leucine-rich repeat kinase 2 (LRRK2), one of the most common genetic causes of familial PD, impair lysosomal degradation within microglia (Zhao et al., 2026)