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These findings indicate that mitochondrial metabolism may support the energetic and metabolic needs of follicular development and oocyte maturation by regulating methylated substrates and cofactors, highlighting a potential interplay between nuclear genome regulation and mitochondrial function

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Enzymes involved in GSH biosynthesis and function like -glutamyl-cysteine ligase and glutathione synthetase are completely dependent on ATP and require magnesium as a cofactor (Bani Younes et al., 2020

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However, as we age, peptide production declines