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The intensity of NIS, encompassing modifications in taste and smell, appetite reduction, and sensations of satiety, is most pronounced during the opening days of chemotherapy, especially within the first week of each cycle [83]

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Its antagonism which can be overcome by increasing the concentration of acetylcholine at receptor sites of the effector organ (e.g., by using anticholinesterase agents which inhibit the enzymatic destruction of acetylcholine) The receptors antagonized by atropine are the peripheral structures that are stimulated or inhibited by muscarine (i.e., exocrine glands, smooth and cardiac muscle)

Inhibition of the sodiumpotassiumchloride cotransporter isoform-1 reduces glioma invasion

[DOI] [PubMed] [Google Scholar] 112.Johnston P.C., Lin Y.K., Walsh R.M., Bottino R., Stevens T.K., Trucco M., Bena J., Faiman C., Hatipoglu B.A