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After the NMDAR and TRPM4 form a complex, the neurons are more vulnerable to excitotoxicity

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Hormonal Hyperpigmentation: Hormonal fluctuations, particularly during pregnancy (melasma gravidarum or pregnancy mask) or due to oral contraceptive use, can lead to the development of hyperpigmentation

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Reason: Stress increases free-radical activity, and poor sleep reduces the body's ability to repair cells and produce antioxidants