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The throat irritation at higher nicotine strengths was a major problem because a nicotine strength of 18 mg/ml is nowhere near what it needs to be in order to produce cigarette-like satisfaction with a very small vape

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When patients indicate a willingness to set a quit date in the next month, clinicians should consider a proactive approach whereby they obtain the patients permission to contact the quit line directly on the patients behalf as opposed to their providing a passive referral (by simply offering the patient contact information for the quit line)

Blackwell Science, p 466 Peedin GF (1999) Production practices: 5A Flue-cured tobacco