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Because the cells cannot efficiently utilize glucose for aerobic energy production, they are forced to rely on inefficient anaerobic glycolysis, leading to a rapid buildup of lactic acid and a profound sense of muscular heaviness and fatigue

Loss of neuronal GSH has also been linked to microglial activation and complement-mediated neurodegeneration, further emphasizing the link between redox imbalance and immune dysregulation (Hashimoto et al., 2023)

253 The methylation of histones is a complicated process that controls the dynamics of chromatin and the transcription of genes

Available online at: 244 YaoS

A 127 kb truncating deletion of PGRMC1 is a novel cause of X-linked isolated paediatric cataract

Taking into account the K D = 34.7 fM ( K D determined from competition with His in the present work) , K D 1 = 3.7 10 9 M and K D 2 = 4.7 10 7 M values for Cu(II)-His complexes at pH 7.4 (taken from 31 ) it can be estimated that approximately 0.7 nM of Cu(II) are bound to His mainly in the form of CuHis 2 complex (Equations are presented in Materials and methods)