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Mechanism mapping (Nature Communications, 2025) Identified the disordered p53 transactivation domain as the binding target, adding structural detail to the mechanism

Stay well-hydrated and monitor for signs of dehydration, especially during GI side effects

Maquart FX, et al

Together these data indicate that D-Nle-Tyr-Ile-NH~ (CH 2 )s-CONH 2 is more metabolically stable than Norleual, possesses an elongated half-life in the circulation and penetrates tissue effectively

The induction of oxalate metabolism in vivo is more effective with functional microbial communities than with functional microbial species

Protein carbonylation in skeletal muscles: impact on function