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Varenicline Trade Names: Chantix, Tyrvaya Drug Class: Nicotinic partial agonist (selective for the 42 subtype) Mechanism of Action: Partial Agonism : Varenicline binds with high affinity and selectivity as a partial agonist to 42 neuronal nicotinic receptors (nAChRs) in the brain (Mihalak et al, 2006

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Using the entire hemisphere as the seed region-of-interest, Viswanath and colleagues showed increased inter-hemispheric FC in sated cigarette smokers as compared to controls, which was positively correlated with the number of cigarettes smoked per day 9

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