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Moreover, MG generates advanced glycation end-products [185] which can reduce the activities of important defense enzymes such as GSTs [186] and cytosolic ascorbate peroxidase [187] by lowering their affinity for their respective substrates

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RT112 cells were transiently transfected with an sgRNA (GCCCCTCCCTAGAGCCTCTG) subcloned in eSpCas9(1.1)-T2A-eGFP (Addgene, 71814) and PLA2G2F_dTAG_HA_Neo with Lipofectamine 3000 and sorted by FACS for GFP-positive cells

Soon, melatonin could be used in preterm infants in the near future 113,114 , with the role of protective molecule against oxidative stress