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In practice, that same additive quality is also the main risk: two strong satiety agents together can suppress appetite and slow the gut more than intended, which is why tolerability not maximum weight effect tends to be the limiting factor in any amylin-plus-incretin discussion

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[ref] Talk with your doctor or pharmacist if you are on prescription medications to see if there is any interaction with any new supplement before you start it

(2016) 150:e1216: 12191230.e6

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Bioorganic & Medicinal Chemistry, 26 (10), 27002707