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doi: 10.1080/2162402X.2017.1349587 105 KwakJWLaskowskiJLiHYMcSharryMVSippelTRBullockBLet al

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Myelokathexis is a congential disorder of the white blood cells, and Xolremdi, an oral CXCR4 antagonist, is designed to mobilize white blood cells such as neutrophils, lymphocytes and monocytes from the bone marrow into the blood to improve immune deficiencies

In health cells, cytosolic NADH is shuttled into mitochondria, where it is turned into NAD + by OXPHOS whereas in cancer cells, the conversion of NAD + to NADH in mitochondria is not sufficient for the high rate of glycolysis due to reduced OXPHOS