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One preclinical study (Valdecantos et al., ADA 2024) showed combination benefit in obese rats

Th17 cells, producing IL-17, IL-21, and IL-22, drive local inflammation, recruit neutrophils, and stimulate fibroblasts and epithelial cells, contributing to tissue damage

Zhou L, Yang Q Neurocase 2022

Sertraline or imipramine significantly decreased the immobility time in cannabis-treated mice by the day 16 and 18 of the study, respectively

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