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4 About the Compound Dihexa is a small synthetic oligopeptide derived from the three N-terminal residues of angiotensin IV (Nle-Tyr-Ile), with structural modifications that block enzymatic degradation, increase lipophilicity, and confer oral bioavailability and blood-brain barrier permeability
They interact closely with nerve cells within the enteric nervous system (ENS), the second brain that governs gut motility, emotion, and inflammation
PepT1 Transporter-Mediated Absorption: KPV utilizes the PepT1 transporter, highly expressed in intestinal epithelial cells, supporting its bioavailability
These effects are associated with the development of anemia and altered drug metabolism [76]
Ksibe A
Preferably, submicron to 250 micron diameter microspheres, are desirable, allowing administration by injection with a standard gauge needle
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