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Oxidative stress impairs SIRT3 activity and transcription by regulating protein carbonylation and transcriptional function of peroxisome proliferator-activated receptor- coactivator-1, leading to mitochondrial dysfunction and activation of the mitochondrial apoptotic pathway via optic atrophy 1 to induce cell death of vitiligo melanocytes [32]

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R., Ji, F., Cohen, E., Ruvkun, G

FOXO4-DRI functions as a competitive inhibitor, displacing p53 from FOXO4, thereby allowing the selective clearance of senescent cells (2, 9)