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This sublingual route of administration bypasses the digestive system, avoiding the first-pass metabolism in the liver, which can significantly reduce the bioavailability of certain medications when taken orally

Severe liver dysfunction, as the liver plays a key role in metabolizing lipotropic compounds

Estimations show that depression has a lifetime prevalence rate of 20% worldwide

10.1016/j.cell.2006.06.046 Cell 37 GrabbeC.HusnjakK.DikicI

Korean Society of Food Science and Technology, 54 (1), 52-58

Phentermine combinations have been used for enhanced appetite suppression, though this requires medical supervision