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Black adults have the highest rate of menthol cigarette use than any other race or ethnic group

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FDA has indicated that evidence from a randomized controlled trial, longitudinal cohort study, or similarly reliable and robust evidence would be required

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Extracts from tobacco rods were serially diluted and superfused over HEK293T cells expressing the human TRPM8 cold/menthol receptor activated by menthol, WS-3 and other synthetic cooling agents, measuring activity by Calcium-microfluorimetry as published (Supplementary file) 3