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[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Gujam FJ, Going JJ, Edwards J, Mohammed ZM, McMillan DC

Sepsis and cerebral dysfunction: BBB damage, neuroinflammation, oxidative stress, apoptosis and autophagy as key mediators and the potential therapeutic approaches

The strongest human clinical evidence is for topical use, including the Leyden 2002 photoaging trial and a 2023 NEEL gel topical study reporting an average 28% increase in skin collagen density at 3 months

10.1017/neu.2015.72 64

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