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RPE dysfunction central to AMD development

In phase I, enzymes such as Cytochrome P450 oxidases introduce reactive or polar groups into xenobiotics

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EVs, as key messengers mediating intercellular communication, have provided a novel perspective for understanding reproductive processes, every critical phase of the reproductive processfrom follicular development and fertilization to embryo implantation and maternal-fetal immune tolerancecan be precisely regulated by EVs (James et al., 2020

Liu L, Wang H, Chen X, Zhang Y, Zhang H, Xie P (2023) Gut microbiota and its metabolites in depression: from pathogenesis to treatment