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Indeed, transgenic mice overexpressing SORLA exhibit decreased A concentrations in brain (Slotte, 1999

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Clemens and Peroh, 2009), possibly including turnover of GS-conjugates (Blum et al., 2007, 2010)

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Laboratories using the compound in time-course or dose-response work should prepare fresh aliquots where possible, recording reconstitution date and storage temperature alongside each experimental block

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