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Blood 122, 2013

Combinations of these factors contributing to low GPx1 activity/levels will result in lower capacity to respond to reactive oxygen species (ROS), favouring accumulation of oxidative damage and promoting tumour progression

The glutathione system is also likely to be active in this scenario to neutralise other sources of cellular ROS that are generated by Dox treatment

Notably, stimuli-responsive platforms enable spatiotemporal control over drug release, optimizing therapeutic efficacy within the tumor microenvironment

Retinal cross sections, histology, and immunofluorescence Both eyes were oriented before enucleation to allow sectioning along the dorsal/ventral axis

For pilot studies or budget-constrained projects where oral administration isn't a factor, the acetate salt remains a viable and economical choice