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Stem-cell derived BBB models are the newest cell type model and have significantly higher expression of tight junction protein and transporters as well as TEER compared to hCMEC/D3 cells [118, 119]
Oxford University Press, Washington Bjrklund G, Skalny AV, Rahman MM, Dadar M, Yassa HA, Aaseth J, Chirumbolo S, Skalnaya MG et al (2018) Toxic metal(loid)-based pollutants and their possible role in autism spectrum disorder
Recommendations are directive statements that an action should (benefits outweigh risks/burdens) or should not (risks/burdens outweigh benefits) be undertaken based on Grade C (low level of certainty) evidence
Guo J, Liu M, Yang D, Bouxsein ML, Thomas CC, Schipani E, et al
In line with previous results obtained in rodent neuronal cultures 43 , we found that the administration of lactate in a concentration range of 520 mM (which are relatively high as compared to physiological ones 19 ) caused an immediate drop in the electrophysiological activity of hiPSCs-derived neuronal networks, in a concentration-dependent manner
Several studies have demonstrated that metformin can alter the composition of the gut microbiota in both healthy individuals (Wu H
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