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By preventing NF-B start, KPV reduces the production of pro-swelling cytokines including TNF-, IL-1, IL-6, and IL-8

May cause temporary redness or mild tingling

Biotransformation (drug metabolism) converts the drug in the body to a metabolite that is more readily excreted, usually by adding a chemical group to the molecule to make it more water soluble

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If the level of pain increases after dosage stabilization, attempt to identify the source of increased pain before increasing the hydrocodone bitartrate and acetaminophen tablets dosage

This is precisely why the titration schedule exists