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Based on the above research findings, we hypothesize that beneficial Clostridium and its metabolites regulate adaptive immunity and induce immune tolerance in RA, thereby synergistically alleviating joint immune damage

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ACS Sustainable Chen Eng 8:831841 Ren A, Liu R, Miao ZG, Zhang X, Cao PF, Chen TX, Li CY, Shi L, Jiang AL, Zhao MW (2017) Hydrogen-rich water regulates effects of ROS balance on morphology, growth and secondary metabolism via glutathione peroxidase in Ganoderma lucidum