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A new tacrine-hydroxamate pan HDACi exhibited inhibitory activity on A1-42 self-aggregation as well as disaggregation activity on pre-formed A fibrils, the pathological markers of AD (Xu et al., 2020)

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A separate 2023 pilot study in the International Journal of Dermatology used 1200mg IV weekly for 10 weeks and reported 22.4% melanin reduction with sustained effect at 12-week follow-up

Hepatic and renal effects Exposure to PET MNPs in vivo can impair hepatic function, as evidenced by structural damage, altered transaminase activity, and redox-inflammatory imbalance

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