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Animal studies measure outcomes after treatment cessation and show maintained structural improvements

Therapeutic modalities of FSP1 inhibitors and rational combinations Multiple chemical strategies have been developed to inhibit FSP1

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If testing in animals and humans reveals 20uM is safe, dose escalation is possible since, according to Figure 3B , the niclosamide concentration can be increased to 30uM at pH 8.07 and 50uM is obtained at only pH 8.31