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Another measurable parameter is heart rate reserve, i.e., the difference between the resting heart rate and the rate during a maximal effort

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This reduction is key for inhibiting the enzymatic activity of 15-lipoxygenase, primarily by converting its non-heme Fe3+ to an inactive Fe2+ state

Hypothyroidism contributes to OxS through an inefficient antioxidant defence system, opposite to hyperthyroidism, where increased ROS production promotes OxS and oxidative damage of thyroid cells ( Figure 1 ) ( 5.1 Thyroid dysfunctions and OxS 5.1.1 Hypothyroidism Even in its subclinical form, hypothyroidism reduces antioxidant system activity, which promotes OxS, causing oxidative damage and altered lipid metabolism in thyroid cells (84)

PLoS One (2014) 9(3):e91769

Arthritis Interception in Patients with Psoriasis Treated with Guselkumab