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doi:10.1192/bjp.bp.112.114389

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Alterations in the localization of F-actin, fibronectin, and thrombospondin occur prior to neoplastic transformation in rat tracheal epithelial cells

Furthermore, CO in the cigarette smoke binds to haemoglobin replacing oxygen with COHb up to 7%15% and this shifts the oxygen dissociation curves to left and will reduce oxygen availability to tissues.[13] Strong affinity of CO for binding to haemoglobin (250 times more than that of oxygen) can be offset by allowing the patients to breath 100% oxygen before anaesthesia induction

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