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Phase I pilot (three healthy male volunteers, subcutaneous administration, 1996, PMID 8637402), increased facial, upper-body, and buttock pigmentation persisting approximately one week after cessation of dosing was reported alongside nausea and somnolence

BH4 treatment resulted in an increase in methionine but this increase was only borderline significant [ F (1, 26) = 3.91, p = 0.06

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Benzyl alcohol helps prevent the growth of most bacteria, allowing the solution to remain sterile under controlled conditions even when accessed multiple times

The study aimed to compare the effects of intermittent fasting with a traditional low-calorie diet on various health parameters, including liver health as assessed by fibro scan and biochemical evaluations

That mix is why skin-science studies focus on it