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Wnt/-catenin signaling plays a protective role in the Mdr2 knockout murine model of cholestaticliver disease

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Under physiological conditions, KEAP1 mediates NRF2s constitutive proteasomal degradation (McMahon et al., 2003) while BACH1 acts as transcriptional antagonist of NRF2s target genes (Zhang and Hannink, 2003)