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Hanniffy et al ., 2011

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GCL is in part regulated by GSH feedback inhibition, thus if GSH is depleted due to oxidative stress, inflammation, or exposure to xenobiotics, de novo synthesis of GSH is upregulated, as is cysteine synthesis

Thus, blocking Gln metabolism could improve the effectiveness of various cancer treatments that target different pathways ( Figure 3 )

Ibrahim MA, Ashour OM, Ibrahim YF, El-Bitar HI, Gomaa W, Abdel-Rahim SR

Similar content being viewed by others Introduction Central to metabolic reprogramming is the dysregulation of Glutamine (Gln) metabolism, which has emerged as a critical aspect of cancer pathophysiology