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Citing Doll and Hill, the journal declared that the most reasonable interpretation of this evidence is that the relationship is one of direct cause and effect. Ronald Fisher begged to differ

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Q: Did any one of the three principal characters come to you first

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The Centers for Disease Control and Prevention (CDC) estimates that 443,000 people die prematurely from smoking or secondhand smoke, and that another 8.6 million live with a serious illness caused by smoking