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Oxid Med Cell Longev 2017;2017:8370593

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The liberation of Nrf2 from Keap1 allows Nrf2 accumulation and translocation to the nucleus (Cuadrado et al., 2019

The general reaction involves formation of an unsymmetrical disulfide from the protectable protein (RSH) and GSH: [24] RSH + GSH + [O] GSSR + H 2 O Glutathione is also employed for the detoxification of methylglyoxal and formaldehyde, toxic metabolites produced under oxidative stress