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WADA (World Anti-Doping Agency): IGF-1 and all analogs, including LR3, are prohibited substances under the S2 category (Peptide Hormones, Growth Factors, and Related Substances)

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The mechanisms of tissue damage in this disease are not fully understood, although it is believed that increased intracellular cystine leads to alteration of GSH levels (Levtchenko et al., 2005)